Highway 231, a major state thoroughfare, passes four miles east of town for north/south access. Highway 57 is available 7 miles west of town for alternate north/south access from the Evansville or Vincennes areas. Highway 58 passes through town for east/west access. The proposed Interstate 69, to be constructed, will be situated approximately five miles from town for easy access to national interstates.
Evansville Regional Airport, Indianapolis International Airport, and the Louisville International Airport offer easily accessible, excellent connections to Odon. Evansville Airport is about 1-1/2 hour south of Odon. The Indianapolis Airport is 1-3/4 hour northeast of Odon. The Louisville International Airport is 2 hours south of Odon. The Daviess County Airport, which is located 30 minutes southwest of Odon in Washington, provides cargo and charter services to various points regionally and nationally.